s100a8 9 (R&D Systems)
R&D Systems is a verified supplier 
R&D Systems manufactures this product 
93
Structured Review
R&D Systems
s100a8 9
S100a8 9, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 16 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/recombinant+mouse+s100a8/Recombinant+Mouse+S100A8+Protein%2C+CF/pmc13098576-222-9-12
Average 93 stars, based on 16 article reviews
S100a8 9, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 16 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/recombinant+mouse+s100a8/Recombinant+Mouse+S100A8+Protein%2C+CF/pmc13098576-222-9-12
Average 93 stars, based on 16 article reviews
s100a8 9 - by Bioz Stars,
2026-10
93/100 stars
Images
1) Product Images from "A neuroimmune axis linking S100A8/9 to itch sensitization in both bullous pemphigoid and atopic dermatitis"
Article Title: A neuroimmune axis linking S100A8/9 to itch sensitization in both bullous pemphigoid and atopic dermatitis
Journal: JID Innovations
doi: 10.1016/j.xjidi.2026.100470
Figure Legend Snippet: Increased S100A8/9 expression in the skin and serum of patients with BP and AD. ( a ) Immunohistochemical analysis with anti-S100A8/9 antibody showing the expression of S100A8/9 in keratinocytes and infiltrating inflammatory cells of lesional skin of patients with BP and AD. S100A8/9 expression was not observed in the healthy skin. Scale bar: 100 μm. (b) Quantification of the expression level of S100A8/9. (control, n = 2; BP, n = 5; AD n = 2). Inter-patient heterogeneity of the expression level of S100A8/9 was observed in the BP skin samples, and representative images of both low and high S100A8/9 expression were shown in A. (c) ELISA analysis showing increased S100A8/9 concentrations in the serum of patients with BP. (control, n = 8; BP, n = 16; P = .0087, Mann-Whitney test). Data are reported as mean ± SD. AD, atopic dermatitis; BP, bullous pemphigoid.
Techniques Used: Expressing, Immunohistochemical staining, Control, Enzyme-linked Immunosorbent Assay, MANN-WHITNEY
Figure Legend Snippet: S100A8/9 directly activates small-diameter, nociceptive DRG sensory neurons. ( a ) Representative fluorescent images of cultured DRG sensory neurons isolated from Pirt GCaMP3/+ mice before and after S100A8/9 (100 ng/ml) application. Arrows point to sensory neurons showing increased GCaMP3 fluorescence levels after S100A8/9 application. (b) Histogram showing size distribution of S100A8/9-responsive neurons. (c–e) Representative traces of DRG neurons evoked by indicated chemicals, including S100A8/9 (100 ng/ml), S100A8 (100 ng/ml), S100A9 (100 ng/ml), capsaicin (1 μM), and KCl (75 mM) in a calcium imaging assay. All S100A8/9-sensitive neurons responded to capsaicin and KCl. The majority of S100A8- and S100A9-responsive neurons also responded to S100A8/9. The three different colors (Red, Green, and Blue) represent individual cells in C-E. (f) TAK-242 inhibited S100A8/9-induced calcium responses in sensory neurons. (n = 3 for both groups P = .018, Welch’s t -test). Data are reported as mean ± SD. AD, atopic dermatitis; BP, bullous pemphigoid; DRG, dorsal root ganglia.
Techniques Used: Cell Culture, Isolation, Fluorescence, Imaging
Figure Legend Snippet: S100A8/9 potentiate histamine-induced itch. ( a ) Subcutaneous injection of S100A8/9 (20 μg/ml) into the nape of the neck of wild-type mice does not induce scratching behavior. (n = 7 for both groups, P = .97, Welch’s t test). (b) Co-injection of S100A8/9 increased histamine (20 mM)-induced scratching behavior. (n = 11 for both groups, P = .038, Welch’s t test). Data are reported as mean ± SD.
Techniques Used: Injection
Related Articles
Recombinant:Article Title: A single-dose Qβ VLP vaccine against S100A9 protein reduces atherosclerosis in a preclinical model. Article Snippet: The standard therapy for cardiovascular disease (CVD) is the administration of statins to reduce plasma cholesterol levels, but this requires lifelong treatment.. A CVD vaccine candidate that targets the pro-inflammatory mediator calprotectin by eliciting antibodies against the S100A9 protein is developed.. The vaccine, based on bacteriophage Qβ virus-like particles (VLPs) displaying S100A9 peptide epitopes, is formulated as a slow-release PLGA:VLP implant by hot–melt extrusion. Article Title: Epithelial Cell-Derived S100 Calcium-Binding Proteins as Key Mediators in the Hallmark Acute Neutrophil Response during Candida Vaginitis Article Snippet: The blots were then washed and incubated with biotinylated anti-goat or anti-sheep secondary antibodies (IgG, 0.1 μg/ml) for 1 h. After washing, the bands were labeled with streptavidin-horseradish peroxidase (HRP) conjugate and visualized with amplified opti-4CN substrate in accordance with the manufacturer's instructions (Bio-Rad). .. Article Title: Epithelial Cell-Derived S100 Calcium-Binding Proteins as Key Mediators in the Hallmark Acute Neutrophil Response during Candida Vaginitis Article Snippet: The blots were then washed and incubated with biotinylated anti-goat or anti-sheep secondary antibodies (IgG, 0.1 μg/ml) for 1 h. After washing, the bands were labeled with streptavidin-horseradish peroxidase (HRP) conjugate and visualized with amplified opti-4CN substrate in accordance with the manufacturer's instructions (Bio-Rad). .. Article Title: Vaginal Epithelial Cell-Derived S100 Alarmins Induced by Candida albicans via Pattern Recognition Receptor Interactions Are Sufficient but Not Necessary for the Acute Neutrophil Response during Experimental Vaginal Candidiasis Article Snippet: .. Article Title: Vaginal Epithelial Cell-Derived S100 Alarmins Induced by Candida albicans via Pattern Recognition Receptor Interactions Are Sufficient but Not Necessary for the Acute Neutrophil Response during Experimental Vaginal Candidiasis Article Snippet: .. Article Title: Epithelial Cell-Derived S100 Calcium-Binding Proteins as Key Mediators in the Hallmark Acute Neutrophil Response during Candida Vaginitis Article Snippet: The blots were then washed and incubated with biotinylated anti-goat or anti-sheep secondary antibodies (IgG, 0.1 g/ml) for 1 h. After washing, the bands were labeled with streptavidin-horseradish peroxidase (HRP) conjugate and visualized with amplified opti-4CN substrate in accordance with the manufacturer’s instructions (Bio-Rad). .. Membrane:Article Title: A single-dose Qβ VLP vaccine against S100A9 protein reduces atherosclerosis in a preclinical model. Article Snippet: The standard therapy for cardiovascular disease (CVD) is the administration of statins to reduce plasma cholesterol levels, but this requires lifelong treatment.. A CVD vaccine candidate that targets the pro-inflammatory mediator calprotectin by eliciting antibodies against the S100A9 protein is developed.. The vaccine, based on bacteriophage Qβ virus-like particles (VLPs) displaying S100A9 peptide epitopes, is formulated as a slow-release PLGA:VLP implant by hot–melt extrusion. Pore Size:Article Title: A single-dose Qβ VLP vaccine against S100A9 protein reduces atherosclerosis in a preclinical model. Article Snippet: The standard therapy for cardiovascular disease (CVD) is the administration of statins to reduce plasma cholesterol levels, but this requires lifelong treatment.. A CVD vaccine candidate that targets the pro-inflammatory mediator calprotectin by eliciting antibodies against the S100A9 protein is developed.. The vaccine, based on bacteriophage Qβ virus-like particles (VLPs) displaying S100A9 peptide epitopes, is formulated as a slow-release PLGA:VLP implant by hot–melt extrusion. Molecular Weight:Article Title: Epithelial Cell-Derived S100 Calcium-Binding Proteins as Key Mediators in the Hallmark Acute Neutrophil Response during Candida Vaginitis Article Snippet: The blots were then washed and incubated with biotinylated anti-goat or anti-sheep secondary antibodies (IgG, 0.1 μg/ml) for 1 h. After washing, the bands were labeled with streptavidin-horseradish peroxidase (HRP) conjugate and visualized with amplified opti-4CN substrate in accordance with the manufacturer's instructions (Bio-Rad). .. Article Title: Epithelial Cell-Derived S100 Calcium-Binding Proteins as Key Mediators in the Hallmark Acute Neutrophil Response during Candida Vaginitis Article Snippet: The blots were then washed and incubated with biotinylated anti-goat or anti-sheep secondary antibodies (IgG, 0.1 μg/ml) for 1 h. After washing, the bands were labeled with streptavidin-horseradish peroxidase (HRP) conjugate and visualized with amplified opti-4CN substrate in accordance with the manufacturer's instructions (Bio-Rad). .. Article Title: Epithelial Cell-Derived S100 Calcium-Binding Proteins as Key Mediators in the Hallmark Acute Neutrophil Response during Candida Vaginitis Article Snippet: The blots were then washed and incubated with biotinylated anti-goat or anti-sheep secondary antibodies (IgG, 0.1 g/ml) for 1 h. After washing, the bands were labeled with streptavidin-horseradish peroxidase (HRP) conjugate and visualized with amplified opti-4CN substrate in accordance with the manufacturer’s instructions (Bio-Rad). .. Enzyme-linked Immunosorbent Assay:Article Title: Epithelial Cell-Derived S100 Calcium-Binding Proteins as Key Mediators in the Hallmark Acute Neutrophil Response during Candida Vaginitis Article Snippet: The blots were then washed and incubated with biotinylated anti-goat or anti-sheep secondary antibodies (IgG, 0.1 μg/ml) for 1 h. After washing, the bands were labeled with streptavidin-horseradish peroxidase (HRP) conjugate and visualized with amplified opti-4CN substrate in accordance with the manufacturer's instructions (Bio-Rad). .. Article Title: Epithelial Cell-Derived S100 Calcium-Binding Proteins as Key Mediators in the Hallmark Acute Neutrophil Response during Candida Vaginitis Article Snippet: The blots were then washed and incubated with biotinylated anti-goat or anti-sheep secondary antibodies (IgG, 0.1 g/ml) for 1 h. After washing, the bands were labeled with streptavidin-horseradish peroxidase (HRP) conjugate and visualized with amplified opti-4CN substrate in accordance with the manufacturer’s instructions (Bio-Rad). .. Derivative Assay:Article Title: Vaginal Epithelial Cell-Derived S100 Alarmins Induced by Candida albicans via Pattern Recognition Receptor Interactions Are Sufficient but Not Necessary for the Acute Neutrophil Response during Experimental Vaginal Candidiasis Article Snippet: .. |